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The most frequently reported adverse events (3%-10% of adult patients) following injection of BOTOX for severe primary axillary hyperhidrosis in double-blind studies include injection-site pain and hemorrhage, nonaxillary sweating, infection, pharyngitis, flu syndrome, headache, fever, neck or back pain, pruritus, and anxiety

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344,347 In addition to increasing the risk of bleeding, this combination causes headaches in an estimated 40% of users